Here is what I see as of now:

Greenwood vs.Brynes or Dorman
Northwestern vs. Laurens
JL Mann vs. TL Hanna
Dutch Fork vs. Rock Hill
Clover vs. Brynes or Dorman
Wren vs. Riverside
Irmo vs. Spartanburg
Mauldin vs. Easley

S. Aiken vs. Spring Valley
James Island vs. S. Florence
Fort Dorchester vs. N. Augusta
Carolina Forest vs. W. Ashley
Wando vs. Lugoff-Elgin
Lexington vs. Summerville
W. Florence vs. Blythewood
Ashley Ridge vs. Aiken

Some good possible matchups:
Mann vs Dutch Fork and Greenwood vs. winner
Irmo vs. Mauldin
S. Aiken Wando in possible 3rd clash

Irmo has tougher road than Wando and will be hard pressed I feel to reach finals.