S. Aiken should be pretty solid with a lot of seniors. I would favor them to win the region and contend for lower state.
As far as Chapin, I don't know about #2 but definitely still up there. they lost a lot of talent but still have a lot from last years team as well as some talented JV players coming up. Never hurts to have a pretty good coach too.
BC will definitely be able to contend as always and Dreher should be competitive even though they had some losses. They have a solid player in #4 Byron (don't know his lastname). He is always a threat to score.