I'm biased as heck (GO GUNNERS), but there's little doubt that of the EPL teams/players that I would select Thierry Henry #1 and Patrick Vieira #2.

Here's some statistics to ponder according to the OPTA INDEX:

EPL

GOALS -- James Beattie (21), Thierry Henry (19), Ruud van Nistelrooy (17), Alan Shearer (16), Mark Viduka-Gianfraco Zola-Michael Owen (13)

ASSISTS -- Thierry Henry (12), Eyal Berkovic-Geremi-Ryan Giggs-Dennis Bergkamp (8)

SHOTS ON TARGET -- Thierry Henry (66), Nicolas Anelka (49), Michael Owen (45), Ruud van Nistelrooy-Harry Kewell (41)

DRIBBLING -- Fabrice Fernandes (184), Thierry Henry (157), Jesper Gronkjaer (147), Jonathan Greening (138), Joe Cole (126)

CLEARANCES -- Sami Hyppia (358), Darren Moore (327), Dean Richards (324), Olof Mellberg (312), Sol Campbell (310)

CROSSING -- David Beckham (80), Fabrice Fernandes (69), Laurent Robert (65), Ian Harte-Geremi (53)

TACKLES -- Sylvain Distin (107), Patrick Vieira (95), Dietmar Hamann (94), Per Frandsden (93), Lucas Neill (92)

DISCIPLINE -- Alan Smith (81 Fouls, 9 Yellow Cards, 1 Red Card), Sean Gregan (68-9-0), Gavin McCann (62-10-0), Gareth Barry (60-9-0), Marc Vivien Foe (66-7-0)

SAVES -- Brad Friedel (125), Mark Schwarzer (121), Kasey Keller (119), Jussi Jaaskelainen (109), Dean Kiely-David James (104)

MY WORLD STARTING 11 -- This would be a good starting point!
F - Thierry Henry (Arsenal)
F - Christian Vieri (Internazionale)
M - Ryan Giggs (Manchester United)
M - Patrick Vieira (Arsenal)
M - Luis Figo (Real Madrid)
M - David Beckham (Manchester United)
D - Fernando Hierro (Real Madrid)
D - Vincent Candela (AS Roma)
D - Mauro Silva (Deportiva de la Coruna)
D - Roberto Carlos (Real Madrid)
GK - Iker Casillas (Real Madrid)

F - Raul (Real Madrid)
M - Rui Costa (AC Milan)
D - Ashley Cole (Arsenal)
GK - Brad Friedel (Blackburn)