One propblem with seeding is going to come up when a region #1 or 2 does not get its home game against a 3 or 4 and the reason given will be well the 3 or 4 was from a stronger region and when the 1 or 2 wins they will cry "FOUL" and "BULL" to the stronger region argument. It will happen a weaker region team will win one and then what do we say? If you want home field win your region, period.

Now if you want to say there are teams in the playoff that should'nt be because a weak region got 4 spots then that might need to get addressed. I would be ok with saying 1st and 2nd place finish in region are set and then the rest of the spots are up for grabs based on a ranking/seeding or play in system system. Maybe make a playoff/in system game for all 3/4/5 seeds (maybe wildcards for 5's) they play on monto get to play the 1/2's on Tues, there now there is an advantage for win/second in region and everyone who is "good" should get a chance.