Cornerflag, "If two teams finish in the same position within their respective Region, the bracket will determine the host.", that is from the 4a handbook. I guess you would have to see the bracket to actually see who would play at home. But as I am looking at it right now I can tell you it is South Aiken that would be hosting Northwestern in the third round on May 6 if both teams win through.
I also see Wando(and these are my picks) hosting Irmo in the second round with the winner playing at the winner of the Dutch Fork/Hilton Head game.

May 4th and May 6th will have some great battles that will leave some good teams behind. Lower state playoffs will again promise some great soccer.